Cell adhesion is facilitated by cell adhesion molecules (CAMs) such as cadherins, integrins, and selectins. These molecules anchor cells to each other and to the extracellular matrix (ECM). Cadherins are involved in homophilic binding, meaning they bind to the same type of molecule on adjacent cells. Integrins link the cell cytoskeleton to the ECM, while selectins mediate transient cell-cell interactions in the bloodstream.