Barrier functions can be compromised in various diseases, leading to increased susceptibility to infections and other complications. For example:
- Inflammatory Bowel Disease (IBD): In conditions like Crohn's disease and ulcerative colitis, the intestinal barrier is disrupted, allowing bacteria and toxins to penetrate the mucosal lining, causing inflammation and damage.
- Eczema: This chronic skin condition is characterized by a defective skin barrier, leading to dryness, increased permeability, and susceptibility to irritants and allergens.
- Cystic Fibrosis: A genetic disorder that affects the respiratory and digestive systems, resulting in thick, sticky mucus that impairs mucociliary clearance and increases the risk of respiratory infections.
