Lipoxins are synthesized through the lipoxygenase pathway. When cells are activated during inflammation, arachidonic acid is released from membrane phospholipids and converted by 15-lipoxygenase (15-LOX) to 15-hydroperoxyeicosatetraenoic acid (15-HPETE). This intermediate is then converted by 5-lipoxygenase (5-LOX) to produce lipoxins such as LXA4 and LXB4.
