The development of disease models typically involves the following steps:
Identification of the Disease: Understanding the clinical features, epidemiology, and molecular basis of the disease. Selection of the Model System: Choosing the appropriate model system (animal, in vitro, ex vivo, or computational) based on the disease characteristics and research objectives. Genetic or Environmental Manipulation: Introducing genetic mutations or environmental factors to induce disease-like conditions in the model system. Validation: Comparing the model system with human disease to ensure it accurately mimics the disease process.
