The formation and maintenance of adherens junctions are regulated by various factors, including:
Calcium Ions: Cadherins are calcium-dependent adhesion molecules. The presence of calcium ions is essential for their adhesive function. Phosphorylation: The phosphorylation of catenins can modulate their binding to cadherins and the actin cytoskeleton, thereby regulating the strength and stability of adherens junctions. Mechanical Forces: Mechanical forces exerted on cells can influence the assembly and disassembly of adherens junctions, allowing tissues to adapt to changing physical environments.
