White pulp - Histology

What is White Pulp?

White pulp is a key component of the spleen, a vital organ in the lymphatic system. It is primarily involved in the immune response and is composed of dense accumulations of lymphocytes and other immune cells. The white pulp is organized around central arteries and typically forms a periarteriolar lymphoid sheath (PALS).

Structure and Organization

The white pulp is organized into several distinct regions. At its core is the central artery, surrounded by the PALS, which is rich in T-lymphocytes. Surrounding the PALS are lymphoid follicles, primarily consisting of B-lymphocytes. Germinal centers may form within these follicles during an active immune response, indicating B-cell proliferation.

Function

The primary function of the white pulp is to initiate immune reactions against antigens in the blood. It filters the blood, trapping antigens and presenting them to lymphocytes. This triggers a series of immune responses, including the activation and proliferation of B-cells and T-cells, and the production of antibodies.

Histological Identification

Under the microscope, white pulp appears as densely packed areas of dark-staining cells within the spleen. Staining techniques such as Hematoxylin and Eosin (H&E) can be used to differentiate white pulp from the surrounding red pulp. The central artery is a key landmark in identifying white pulp.

Clinical Relevance

Understanding the histology of white pulp is crucial for diagnosing various spleen disorders. Conditions such as splenomegaly, lymphoma, and infections can alter the structure and function of the white pulp. Histological examination can provide insights into these alterations, aiding in diagnosis and treatment.

Research and Advances

Recent research has focused on understanding the role of white pulp in systemic autoimmune diseases and cancers. Advances in immunohistochemistry and molecular biology have enhanced our ability to study the cellular and molecular mechanisms within the white pulp, leading to potential new therapeutic strategies.

Relevant Publications

Insights into microstructure and expression of markers of proliferation, apoptosis and T cells in the spleen of cattle egret (Bubulcus ibis).

Issue Release: 2024

Fungal behavior and recent developments in biopulping technology.

Issue Release: 2024

Glomerular Hypertrophy and Splenic Red Pulp Degeneration Concurrent with Oxidative Stress in 3xTg-AD Mice Model for Alzheimer\'s Disease and Its Exacerbation with Sex and Social Isolation.

Issue Release: 2024

Cannabidiol - an effective analgesic for toothache?

Issue Release: 2024

Porcine Brain Enzyme Hydrolysate Enhances Immune Function and Antioxidant Defense via Modulation of Gut Microbiota in a Cyclophosphamide-Induced Immunodeficiency Model.

Issue Release: 2024

A decade of neglecting sublingual mass: A case report of epidermoid cyst.

Issue Release: 2024

MALDI imaging mass spectrometry visualizes the distribution of antidepressant duloxetine and its major metabolites in mouse brain, liver, kidney, and spleen tissues.

Issue Release: 2024

Poor oral health is associated with inflammation, aortic valve calcification, and brain volume among forager-farmers.

Issue Release: 2024

[Mechanism of IL-17 Signaling Pathway in Spleen Inflammatory Response Induced by Altitude Hypoxia in Mice].

Issue Release: 2024

Zeb2 drives the formation of CD11c + atypical B cells to sustain germinal centers that control persistent infection.

Issue Release: 2024

15--Phytoene Desaturase and 15--Phytoene Synthase Can Catalyze the Synthesis of β-Carotene and Influence the Color of Apricot Pulp.

Issue Release: 2024

Shear bond strength of calcium silicate-based cements to glass ionomers.

Issue Release: 2024

One-year Radiographic and Clinical Performance of Bioactive Materials in Primary Molar Pulpotomy: A Randomized Controlled Trial.

Issue Release: 2024

HPLC-ESI/MS-MS metabolic profiling of white pitaya fruit and cytotoxic potential against cervical cancer: Comparative studies, synergistic effects, and molecular mechanistic approaches.

Issue Release: 2024

Immunophysiological State of Dogs According to the Immunoregulatory Index of Their Blood and Spleens.

Issue Release: 2024

Effects of cage vs. net-floor mixed rearing system on goose spleen histomorphology and gene expression profiles.

Issue Release: 2024

Blood defense system - Proposal for a new concept of an immune system against blood borne pathogens comprising the liver, spleen and bone marrow.

Issue Release: 2024

Changes in splenic tissue and immune response profile of Schistosoma mansoni infected mice submitted to chronic ethanol intake.

Issue Release: 2024

A novel AA14 LPMO from Talaromyces rugulosus with bifunctional cellulolytic/hemicellulolytic activity boosted cellulose hydrolysis.

Issue Release: 2024

Vaccine Development for Severe Fever with Thrombocytopenia Syndrome Virus in Dogs.

Issue Release: 2024

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