SPATA16 - Histology

What is SPATA16?

SPATA16 (Spermatogenesis Associated 16) is a gene that encodes a protein involved in the process of spermatogenesis. This process is crucial for the production of mature spermatozoa from spermatogonial stem cells in the testes.

Where is SPATA16 Located?

SPATA16 is located on chromosome 3 in humans. It is highly expressed in the testis, particularly in the germ cells, which are essential for reproduction.

What Role Does SPATA16 Play in Spermatogenesis?

The protein encoded by SPATA16 is involved in the formation and maturation of spermatozoa. It participates in various stages of cell differentiation and development within the seminiferous tubules of the testes.

What Happens When SPATA16 is Mutated?

Mutations in the SPATA16 gene can lead to male infertility. Such mutations can disrupt the normal process of spermatogenesis, resulting in oligospermia (low sperm count) or azoospermia (absence of sperm).

How is SPATA16 Studied in Histology?

In histological studies, SPATA16 can be analyzed using various techniques such as immunohistochemistry (IHC) and in situ hybridization (ISH). These methods allow researchers to visualize the expression and localization of SPATA16 in tissue sections.

What Are the Clinical Implications of SPATA16 Mutations?

Clinically, identifying mutations in SPATA16 can assist in the diagnosis and treatment of certain types of male infertility. Genetic testing for SPATA16 mutations can be a part of the evaluation process for men with unexplained infertility issues.

Are There Any Current Treatments for SPATA16-Related Infertility?

Currently, there are no specific treatments targeting SPATA16-related infertility. However, assisted reproductive technologies (ART) such as in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) can be used to help affected individuals achieve pregnancy.

What Are Future Directions for Research on SPATA16?

Future research on SPATA16 may focus on understanding the precise molecular mechanisms by which it influences spermatogenesis. Additionally, developing therapies that can correct or compensate for SPATA16 mutations could offer new avenues for treating male infertility.

Relevant Publications

Molecular quantitative trait loci in reproductive tissues impact male fertility in cattle.

Issue Release: 2024

A homozygous missense mutation in the fibroblast growth factor 5 gene is associated with the long-hair trait in Angora rabbits.

Issue Release: 2023

Meta-GWAS on PCSK9 concentrations reveals associations of novel loci outside the PCSK9 locus in White populations.

Issue Release: 2023

SPATA16 promoter hypermethylation and downregulation in male infertility.

Issue Release: 2022

Single-Nucleotide Polymorphism on Spermatogenesis Associated 16 Gene-Coding Region Affecting Bovine Leukemia Virus Proviral Load.

Issue Release: 2022

Mixed model-based eQTL analysis reveals lncRNAs associated with regulation of genes involved in sex determination and spermatogenesis: The key to understanding human gender imbalance.

Issue Release: 2022

Association of CATSPER1, SPATA16 and TEX11 genes polymorphism with idiopathic azoospermia and oligospermia risk in Iranian population.

Issue Release: 2022

Single-center thorough evaluation and targeted treatment of globozoospermic men.

Issue Release: 2021

Autosomal recessive loci contribute significantly to quantitative variation of male fertility in a dairy cattle population.

Issue Release: 2021

Population-specific, recent positive directional selection suggests adaptation of human male reproductive genes to different environmental conditions.

Issue Release: 2020

Exome sequencing reveals novel causes as well as new candidate genes for human globozoospermia.

Issue Release: 2020

Genetic analyses of a large cohort of infertile patients with globozoospermia, DPY19L2 still the main actor, GGN confirmed as a guest player.

Issue Release: 2020

Identification and treatment of men with phospholipase Cζ-defective spermatozoa.

Issue Release: 2020

Comparison of sperm morphology and nuclear sperm quality in SPATA16- and DPY19L2-mutated globozoospermic patients.

Issue Release: 2019

[Advances in the studies of teratospermia-related genes].

Issue Release: 2018

Genome-wide differential methylation analyses identifies methylation signatures of male infertility.

Issue Release: 2018

Embryos derived from couples with consanguineous marriages with globozoospermia should be screened for gender or DPY19L2 deletion.

Issue Release: 2018

Human Globozoospermia-Related Gene Spata16 Is Required for Sperm Formation Revealed by CRISPR/Cas9-Mediated Mouse Models.

Issue Release: 2017

Risk prediction of pulmonary tuberculosis using genetic and conventional risk factors in adult Korean population.

Issue Release: 2017

A new mutation identified in SPATA16 in two globozoospermic patients.

Issue Release: 2016

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