Myeloid Progenitor cells - Histology

What are Myeloid Progenitor Cells?

Myeloid progenitor cells, also known as common myeloid progenitors (CMPs), are a type of stem cell found in the bone marrow. They play a crucial role in the hematopoietic system, where they give rise to various myeloid lineage cells. These progenitor cells are essential in the formation and maintenance of the body's blood and immune systems.

Lineage and Differentiation

Myeloid progenitor cells differentiate into several key cell types, including erythrocytes (red blood cells), megakaryocytes (the precursors to platelets), granulocytes (such as neutrophils, eosinophils, and basophils), and monocytes (which can differentiate further into macrophages and dendritic cells).

Histological Identification

In histological studies, myeloid progenitor cells can be identified using specific markers and staining techniques. One of the most common markers is CD34, which is expressed on the surface of hematopoietic stem cells and progenitor cells. Immunohistochemistry (IHC) and flow cytometry are often used to detect these markers and distinguish myeloid progenitors from other cell types.

Role in Disease

Myeloid progenitor cells are implicated in various hematological disorders and cancers. For instance, in acute myeloid leukemia (AML), these progenitor cells undergo malignant transformation, leading to uncontrolled proliferation and accumulation of immature myeloid cells in the bone marrow and blood. This disrupts normal hematopoiesis and results in severe clinical manifestations.

Therapeutic Potential

Given their pivotal role in blood formation, myeloid progenitor cells have significant therapeutic potential. They can be used in bone marrow transplants to treat conditions such as leukemia, lymphoma, and other hematopoietic disorders. Research is also ongoing to explore their use in regenerative medicine and in the treatment of genetic blood disorders through gene therapy.

Research and Future Directions

Current research on myeloid progenitor cells is focused on understanding the molecular mechanisms that regulate their differentiation and proliferation. This knowledge could lead to the development of targeted therapies for hematological diseases. Additionally, scientists are investigating the potential of stem cell engineering to create myeloid progenitor cells from induced pluripotent stem cells (iPSCs), which could provide a renewable source of cells for therapeutic applications.

Relevant Publications

[Clinical characteristics of myeloid tumors combined with the proliferation of large granular lymphocytes].

Issue Release: 2024

Targeted knock-in of cDNA into the locus leads to myeloid phenotypic correction of p47 -deficient chronic granulomatous disease.

Issue Release: 2024

Activation of non-classical Wnt signaling pathway effectively enhances HLA-A presentation in acute myeloid leukemia.

Issue Release: 2024

CAR-T Cells in Acute Myeloid Leukemia: Where Do We Stand?

Issue Release: 2024

Molecular Interactions of Selective Agonists and Antagonists with the Retinoic Acid Receptor γ.

Issue Release: 2024

CD74 facilitates immunotherapy response by shaping the tumor microenvironment of hepatocellular carcinoma.

Issue Release: 2024

An Investigation of the Inflammatory Landscape in the Brain and Bone Marrow of the APP/PS1 Mouse.

Issue Release: 2024

Cxcl10 and Cxcr3 regulate self-renewal and differentiation of hematopoietic stem cells.

Issue Release: 2024

Prolonged Cadmium Exposure and Osteoclastogenesis: A Mechanistic Mouse and Study.

Issue Release: 2024

BRD9 regulates normal human hematopoietic stem cell function and lineage differentiation.

Issue Release: 2024

Not just for lymphoid cells: The role of the noncanonical NF-κB signaling pathway in early and late myelopoiesis with a focus on hypereosinophilic disorders.

Issue Release: 2024

\"Myeloid\" Mutations in ALL Are Not Uncommon: Implications for Etiology and Therapies.

Issue Release: 2024

CUX1 regulates human hematopoietic stem cell chromatin accessibility via the BAF complex.

Issue Release: 2024

miRNA-7145-cuedc2 axis controls hematopoiesis through JAK1/STAT3 signaling pathway.

Issue Release: 2024

Mis-expression of GATA6 re-programs cell fate during early hematopoiesis.

Issue Release: 2024

Mapping Lung Hematopoietic Progenitors: Developmental Kinetics and Response to Influenza A Infection.

Issue Release: 2024

Microbial cancer immunotherapy reprograms hematopoietic stem cells to enhance anti-tumor immunity.

Issue Release: 2024

Donor-derived anti-HLA antibodies in a haploidentical hematopoietic cell transplant recipient shortly after transplant.

Issue Release: 2024

Mathematical modelling of stem and progenitor cell dynamics during ruxolitinib treatment of patients with myeloproliferative neoplasms.

Issue Release: 2024

Dysregulated innate immune signaling cooperates with RUNX1 mutations to transform an MDS-like disease to AML.

Issue Release: 2024

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