Microbubble Technology - Histology

What is Microbubble Technology?

Microbubble technology involves the use of tiny, gas-filled bubbles that can be injected into the bloodstream. These microbubbles are typically stabilized by a shell made of lipids, proteins, or polymers. In the context of histology, microbubbles have been increasingly utilized for their ability to enhance imaging and therapeutic modalities.

How Do Microbubbles Enhance Imaging?

Microbubbles are primarily used as contrast agents in ultrasound imaging. Their high echogenicity allows for improved visualization of blood flow and tissue vascularity. When microbubbles are exposed to ultrasound waves, they oscillate and produce strong echo signals, enhancing the contrast of the images. This is particularly useful in identifying pathological changes in tissues, such as tumors or inflammatory processes.

What are the Applications of Microbubble Technology in Histology?

Microbubble technology has several applications in histology, including:

Targeted Drug Delivery: Microbubbles can be loaded with therapeutic agents and directed to specific tissues using ultrasound, allowing for localized treatment and reducing systemic side effects.
Molecular Imaging: Microbubbles can be functionalized with ligands or antibodies to bind to specific cellular markers, enabling the detailed study of tissue architecture and cellular interactions.
Histopathological Assessment: Enhanced imaging through microbubbles facilitates more accurate and earlier detection of pathological changes, aiding in the diagnosis and monitoring of diseases.

What are the Advantages of Using Microbubbles in Histological Studies?

The use of microbubble technology in histological studies offers several advantages:

Non-Invasiveness: Microbubble-enhanced imaging is generally non-invasive, reducing the need for biopsies and surgical interventions.
Real-Time Imaging: The technology allows for real-time monitoring, which is crucial for dynamic studies such as blood flow and tissue perfusion.
High Sensitivity and Specificity: The enhanced contrast improves the detection of subtle histological changes, leading to more accurate diagnoses.

What are the Limitations and Challenges?

Despite its advantages, microbubble technology also has some limitations and challenges:

Short Lifespan: Microbubbles have a limited lifespan in the bloodstream, which can restrict the duration of imaging studies.

Relevant Publications

Microbubble-Enhanced Focused Ultrasound for Infiltrating Gliomas.

Issue Release: 2024

Bibliometric and visualized analysis of ultrasound combined with microbubble therapy technology from 2009 to 2023.

Issue Release: 2024

Ultrasound‑targeted microbubble destruction technology delivering β‑klotho to the heart enhances FGF21 sensitivity and attenuates heart remodeling post‑myocardial infarction.

Issue Release: 2024

Nanobubble applications in aquaculture industry for improving harvest yield, wastewater treatment, and disease control.

Issue Release: 2024

A multicellular brain spheroid model for studying the mechanisms and bioeffects of ultrasound-enhanced drug penetration beyond the blood‒brain barrier.

Issue Release: 2024

Ultrasound-targeted microbubble technology facilitates SAHH gene delivery to treat diabetic cardiomyopathy by activating AMPK pathway.

Issue Release: 2024

Quality assurance for focused ultrasound-induced blood-brain barrier opening procedure using passive acoustic detection.

Issue Release: 2024

Characterization of focused ultrasound blood-brain barrier disruption effect on inflammation as a function of treatment parameters.

Issue Release: 2024

A patient-derived amyotrophic lateral sclerosis blood-brain barrier model for focused ultrasound-mediated anti-TDP-43 antibody delivery.

Issue Release: 2024

Application of microbubble air flotation to harvest Microcystis sp. from agriculture wastewater: The regulation and mechanisms.

Issue Release: 2024

A review of multiparametric ultrasound imaging in the clinical setting: scrotal contents.

Issue Release: 2024

Ultrasound Controllable Release of Proteolysis Targeting Chimeras for Triple-Negative Breast Cancer Treatment.

Issue Release: 2024

A High Sensitivity CMUT-Based Passive Cavitation Detector for Monitoring Microbubble Dynamics During Focused Ultrasound Interventions.

Issue Release: 2024

Potentiation of anti-angiogenic eNOS-siRNA transfection by ultrasound-mediated microbubble destruction in ex vivo rat aortic rings.

Issue Release: 2024

Ammonia production by microbubbles: A theoretical analysis of achievable energy intensity.

Issue Release: 2024

Ethanologenic fermentation by Parageobacillus thermoglucosidasius with continuous hot microbubble gas-stripping.

Issue Release: 2024

Precision medicine focus on the central nervous system: Non-invasive therapeutic agent delivery with focused ultrasound and microbubbles.

Issue Release: 2024

Ultrasound Microbubble-Stimulated miR-145-5p Inhibits Malignant Behaviors of Breast Cancer Cells by Targeting ACTG1.

Issue Release: 2024

A One-Stone-Two-Birds Strategy of Targeting Microbubbles with \"Dual\" Anti-Inflammatory and Blood-Brain Barrier \"Switch\" Function for Ischemic Stroke Treatment.

Issue Release: 2024

A study on the bio-based surfactant sodium cocoyl alaninate as a foaming agent for enhanced oil recovery in high-salt oil reservoirs.

Issue Release: 2024

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