FA Core Complex - Histology

What is the FA Core Complex?

The FA Core Complex refers to a group of proteins involved in the DNA damage response, specifically related to the Fanconi Anemia (FA) pathway. This pathway is crucial for the repair of DNA interstrand crosslinks (ICLs), which are lesions that can interfere with DNA replication and transcription.

Components of the FA Core Complex

The FA Core Complex consists of several proteins, including FANCA, FANCB, FANCC, FANCD2, and others. These proteins work together to monoubiquitinate FANCD2 and FANCI, which are key steps in the FA pathway for DNA repair.

Function in DNA Repair

The primary function of the FA Core Complex is to recognize and repair DNA ICLs. When an ICL is detected, the FA Core Complex is activated and facilitates the monoubiquitination of FANCD2 and FANCI. This process is essential for recruiting downstream repair proteins, including those involved in homologous recombination and nucleotide excision repair.

Role in Histology

In histology, the study of the FA Core Complex helps us understand the cellular response to DNA damage and the mechanisms behind genetic stability. Abnormalities in the FA pathway can lead to genomic instability, contributing to various diseases, including Fanconi Anemia itself and certain types of cancer.

Clinical Implications

Mutations in any component of the FA Core Complex can result in Fanconi Anemia, a rare genetic disorder characterized by bone marrow failure, congenital abnormalities, and a predisposition to cancer. Understanding the FA pathway at the histological level aids in diagnosing and developing potential therapeutic strategies for these conditions.

Research and Future Directions

Ongoing research focuses on elucidating the precise mechanisms by which the FA Core Complex and its associated proteins contribute to DNA repair. Advances in this field may lead to novel treatments for FA and other disorders related to DNA damage repair deficiencies. Techniques such as CRISPR-Cas9 and gene therapy are being explored to correct mutations in the FA genes, offering hope for more effective interventions in the future.

Relevant Publications

[Homozygous Variant of of the Fanconi Anemia Pathway Causes Premature Ovarian Insufficiency: Investigation of the Pathogenic Mechanism].

Issue Release: 2024

A minimal Fanconi Anemia complex in early diverging fungi.

Issue Release: 2024

Identifying an AML Prognostic Model Using 10 Marker Genes from Single-Cell Transcriptome and Bulk Transcriptome Analysis.

Issue Release: 2024

Development of Magnetic Nanosystems with Potential for the Treatment of Inner Ear Pathologies.

Issue Release: 2024

The role of cattle manure-driven polysaccharide precursors in humus formation during composting of spent mushroom substrate.

Issue Release: 2024

The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks.

Issue Release: 2024

The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance.

Issue Release: 2024

FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition.

Issue Release: 2024

Accuracy and Comparison of Core Needle Biopsy Diagnoses With Excision Specimen for Diagnosing Fibroepithelial Lesions of the Breast.

Issue Release: 2024

KANK1 shapes focal adhesions by orchestrating protein binding, mechanical force sensing, and phase separation.

Issue Release: 2023

Fanconi anemia associated protein 20 (FAAP20) plays an essential role in homology-directed repair of DNA double-strand breaks.

Issue Release: 2023

Research progress of the Fanconi anemia pathway and premature ovarian insufficiency.

Issue Release: 2023

C1orf112 teams up with FIGNL1 to facilitate RAD51 filament disassembly and DNA interstrand cross-link repair.

Issue Release: 2023

Pan-cancer analysis of the prognostic and immunological role of Fanconi anemia complementation group E.

Issue Release: 2023

High FAAP24 expression reveals poor prognosis and an immunosuppressive microenvironment shaping in AML.

Issue Release: 2023

A C57BL/6J Fancg-KO Mouse Model Generated by CRISPR/Cas9 Partially Captures the Human Phenotype.

Issue Release: 2023

The Fanconi anemia core complex promotes CtIP-dependent end-resection to drive homologous recombination at DNA double-strand breaks.

Issue Release: 2023

FAAP100 is required for the resolution of transcription-replication conflicts in primordial germ cells.

Issue Release: 2023

Ductal carcinoma in situ arising from fibroadenoma; a rare case with review of literature.

Issue Release: 2022

Fancb deficiency causes premature ovarian insufficiency in mice†.

Issue Release: 2022

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