Epigallocatechin Gallate (EGCG) - Histology

What is Epigallocatechin Gallate (EGCG)?

Epigallocatechin gallate (EGCG) is a type of catechin, a natural phenol, and antioxidant. It is most abundantly found in green tea. EGCG is known for its potent health benefits, including anti-inflammatory, anti-cancer, and antioxidant properties.

How does EGCG function at the cellular level?

EGCG exerts its effects by interacting with various molecular pathways within the cell. It can inhibit cell proliferation, induce apoptosis, and reduce oxidative stress. These actions are crucial in preventing cellular damage and maintaining cellular integrity.

What are the histological effects of EGCG?

Histologically, EGCG has been shown to have several beneficial effects. For example, it can reduce the size and number of inflammatory cells in tissue samples. Additionally, in cancer studies, EGCG has been observed to decrease the rate of cell division in tumor cells, leading to smaller tumor sizes in histological sections.

How is EGCG used in histological studies?

EGCG is often used in experimental histology to study its effects on various tissues. Researchers may treat cells or tissues with EGCG and then use histological staining techniques to observe changes in tissue architecture, cell morphology, and the presence of specific biomarkers.

What are some specific tissues affected by EGCG?

EGCG has been shown to affect various tissues. For instance, in liver tissue, it can reduce fat accumulation and fibrosis. In skin, EGCG promotes wound healing and reduces inflammation. In the brain, it has neuroprotective effects, reducing the damage from oxidative stress and inflammatory responses.

What are the limitations of using EGCG in histological studies?

While EGCG has many potential benefits, there are limitations in its use. One major limitation is its bioavailability, as EGCG is not easily absorbed by the body. Additionally, high doses of EGCG can be toxic to cells, which may complicate its use in therapeutic applications.

Future directions in EGCG research

Future research in EGCG is likely to focus on improving its bioavailability and understanding its molecular targets in greater detail. Additionally, there is ongoing research into the use of EGCG in combination with other treatments to enhance its therapeutic effects. Overall, EGCG holds great promise in the field of histology and medicine.

Relevant Publications

Injectable cross-linked hyaluronic acid hydrogels with epigallocatechin gallate loading as vitreous substitutes.

Issue Release: 2024

[Investigation of Mechanism of Creming-down Phenomenon and Development of High-order Functions Using Tea Catechins].

Issue Release: 2024

Influence of EGCG oxidation on inhibitory activity against the SARS-CoV-2 main protease.

Issue Release: 2024

Epigallocatechin gallate modulates ferroptosis through downregulation of tsRNA-13502 in non-small cell lung cancer.

Issue Release: 2024

The physiological levels of epigallocatechin gallate (EGCG) enhance the Cd-induced oxidative stress and apoptosis in CHO-K1 cells.

Issue Release: 2024

Epigallocatechin-3-gallate Inhibits LPS/AβO-induced Neuroinflammation in BV2 Cells through Regulating the ROS/TXNIP/NLRP3 Pathway.

Issue Release: 2024

(-)-Epigallocatechin gallate as an inhibitor of hemoglobin-catalyzed lipid oxidation: molecular mechanism of action and nutritional application.

Issue Release: 2024

Effect of Milk Protein-Polyphenol Conjugate on the Regulation of GLP-1 Hormone.

Issue Release: 2024

Whey Protein Sodium-Caseinate as a Deliverable Vector for EGCG: In Vitro Optimization of Its Bioaccessibility, Bioavailability, and Bioactivity Mode of Actions.

Issue Release: 2024

(-)-epigallocatechin 3-gallate protects pancreatic β-cell against excessive autophagy-induced injury through promoting FTO degradation.

Issue Release: 2024

The therapeutic potential of typical plant-derived compounds for the management of metabolic disorders.

Issue Release: 2024

Protective effects of EGCG on acrolein-induced and its mechanism of life extension.

Issue Release: 2024

Epigallocatechin-3-gallate inhibits osteogenic differentiation of vascular smooth muscle cells through the transcription factor JunB.

Issue Release: 2024

Phenolic compounds from : a multifaceted approach to antioxidant, anti-inflammatory, anticancer, and anti-influenza activities.

Issue Release: 2024

Carbon Dot-Based Photo-Cross-Linked Gelatin Methacryloyl Hydrogel Enables Dental Pulp Regeneration: A Preliminary Study.

Issue Release: 2024

Antibacterial Activity of Epigallocatechin-3-gallate (EGCG) Loaded Lipid-chitosan Hybrid Nanoparticle against Planktonic Microorganisms.

Issue Release: 2024

Effects of the Taste Substances and Metal Cations in Green Tea Infusion on the Turbidity of EGCG-Mucin Mixtures.

Issue Release: 2024

A Zn cross-linked sodium alginate/epigallocatechin gallate hydrogel scaffold for promoting skull repair.

Issue Release: 2024

The Protection of EGCG Against 6-OHDA-Induced Oxidative Damage by Regulating PPARγ and Nrf2/HO-1 Signaling.

Issue Release: 2024

Highly Effective Nobiletin-MPN in Yeast Microcapsules for Targeted Modulation of Oxidative Stress, NLRP3 Inflammasome Activation, and Immune Responses in Ulcerative Colitis.

Issue Release: 2024

What is Liver Pathology?

Why is Surface Area Important?

What is Dark Field Microscopy?

How Does ChIP Work?

What Role Do Stem Cells Play in Tissue Regeneration?

What Role Does Technology Play in Improving Labeling?

How is Monitoring Conducted?

How is Ct Used in Histological Studies?

What are Assistive Devices in Histology?

How to Implement Workflow Automation in Histology?

Partnered Content Networks

Relevant Topics