Sulfonamides - Histology

What are Sulfonamides?

Sulfonamides, also known as sulfa drugs, are a group of synthetic antimicrobial agents that contain the sulfonamide group. These compounds are structurally similar to para-aminobenzoic acid (PABA), a substance necessary for bacterial growth.

Mechanism of Action

Sulfonamides exert their effect by inhibiting the dihydropteroate synthase enzyme involved in the folate synthesis pathway. This competitive inhibition leads to a decrease in the production of dihydrofolic acid, ultimately disrupting DNA synthesis and cell replication in bacteria.

Histological Applications of Sulfonamides

In the field of histology, sulfonamides can serve various purposes:

Antimicrobial agents in tissue sample preparation.
Staining procedures in microbiological histology.
Infection control in cell and tissue culture.

Challenges and Considerations

While sulfonamides are effective, they also come with challenges:

Bacterial resistance due to mutations or acquisition of resistance genes.
Allergic reactions in some individuals.
Toxicity concerns, especially in high doses or prolonged use.

Future Directions

Research continues to explore new sulfonamide derivatives with improved efficacy and reduced side effects. Advances in histological techniques also promise more precise and effective applications of sulfonamides in pathology and microbiology.

Conclusion

Sulfonamides play a crucial role in histology, particularly in preventing contamination and aiding in microbial studies. Despite their challenges, ongoing research and innovation promise to enhance their utility and efficacy in histological practices.

Relevant Publications

EDA Complex-Promoted Cascade Cyclization of Alkynes Enabling the Rapid Assembly of 3-Sulfonylindoles and Vinyl Sulfone Oxindoles.

Issue Release: 2024

Nitrogen stable isotope analysis of sulfonamides by derivatization-gas chromatography-isotope ratio mass spectrometry.

Issue Release: 2024

General performance, kinetic modification, and key regulating factor recognition of microalgae-based sulfonamide removal.

Issue Release: 2024

Four novel Acinetobacter lwoffii strains isolated from the milk of cows in China with subclinical mastitis.

Issue Release: 2024

Moderate and serious adverse reactions to antimicrobials among hospitalized children: A systematic review.

Issue Release: 2024

Efficient and Sustainable Electrosynthesis of -Sulfonyl Iminophosphoranes by the Dehydrogenative P-N Coupling Reaction.

Issue Release: 2024

Biodegradation of Photocatalytic Degradation Products of Sulfonamides: Kinetics and Identification of Intermediates.

Issue Release: 2024

New biologically active sulfonamides as potential drugs for Alzheimer\'s disease.

Issue Release: 2024

Discovery and development of thiazolidine-2,4-dione derivatives as Bcl-2/Mcl-1 dual inhibitors.

Issue Release: 2024

Occurrence and Distribution of Antibacterial Quaternary Ammonium Compounds in Chinese Estuaries Revealed by Machine Learning-Assisted Mass Spectrometric Analysis.

Issue Release: 2024

Antimicrobial Resistance Patterns of Outpatient Staphylococcus aureus Isolates.

Issue Release: 2024

Preoperative survey to evaluate the patients\' allergy list and its relevance to perioperative care.

Issue Release: 2024

Cyclodextrin-based ternary supramolecular deep eutectic solvents for efficient extraction and analysis of trace quinolones and sulfonamides in wastewater by adjusting pH.

Issue Release: 2024

Anthropogenic activities drive the distribution and ecological risk of antibiotics in a highly urbanized river basin.

Issue Release: 2024

Metal-Free Photoredox Catalyzed Sulfonylation of Phenylhydrazines with Thiols.

Issue Release: 2024

Acyl pyrazole sulfonamides as new antidiabetic agents: synthesis, glucosidase inhibition studies, and molecular docking analysis.

Issue Release: 2024

2-Pyridone-Directed Cu-Catalyzed General Method of C(sp)-H Activation for C-S, C-Se, and C-N Cross-Coupling: Easy Access to Aryl Thioethers, Selenide Ethers, and Sulfonamides and DFT Study.

Issue Release: 2024

Sulfonamide-induced DNA hypomethylation disturbed sugar metabolism in rice (Oryza sativa L.).

Issue Release: 2024

Cryptic environmental conjugative plasmid recruits a novel hybrid transposon resulting in a new plasmid with higher dispersion potential.

Issue Release: 2024

Sulfonamides as anticancer agents: A brief review on sulfonamide derivatives as inhibitors of various proteins overexpressed in cancer.

Issue Release: 2024

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