Preganglionic Fibers - Histology

What are Preganglionic Fibers?

Preganglionic fibers are nerve fibers that originate from the central nervous system (CNS) and extend to a ganglion in the autonomic nervous system (ANS). These fibers are crucial for the transmission of nerve signals from the CNS to the target organs, facilitating involuntary physiological functions.

Where are Preganglionic Fibers Located?

In the sympathetic nervous system, preganglionic fibers arise from the thoracic and lumbar regions of the spinal cord, specifically from the intermediolateral cell columns. In the parasympathetic nervous system, they originate from the brainstem and sacral spinal cord regions.

What is the Structure of Preganglionic Fibers?

Preganglionic fibers are typically myelinated, which means they are covered by a protective sheath known as myelin. This myelination allows for faster transmission of nerve impulses. These fibers are generally shorter in the sympathetic nervous system compared to the parasympathetic nervous system.

What Neurotransmitters are Involved?

The primary neurotransmitter released by preganglionic fibers is acetylcholine (ACh). This neurotransmitter binds to receptors on the postganglionic neurons, leading to the continuation of the nerve signal.

How are Preganglionic Fibers Studied in Histology?

Histologically, preganglionic fibers can be studied using various staining techniques that highlight nervous tissue. Common methods include immunohistochemistry to detect specific proteins and electron microscopy to observe ultrastructural details.

What are the Functions of Preganglionic Fibers?

Preganglionic fibers play a pivotal role in the regulation of autonomic functions such as heart rate, digestion, respiratory rate, and glandular secretion. They act as intermediaries that transmit signals from the CNS to the autonomic ganglia.

What are Some Common Disorders Involving Preganglionic Fibers?

Damage or dysfunction in preganglionic fibers can lead to a range of disorders, including autonomic neuropathy, characterized by impaired autonomic functions. Another condition, Horner's syndrome, involves the disruption of sympathetic preganglionic fibers.

Conclusion

Understanding preganglionic fibers in the context of histology provides valuable insights into their structure, function, and role in maintaining autonomic control. Continued research in this area is essential for advancing knowledge on related disorders and potential therapeutic approaches.

Relevant Publications

Parotid hypersalivation after inferior salivatory nucleus glutamate/NMDA receptor excitation in the rat.

Issue Release: 2024

The differences in the anatomy of the thoracolumbar and sacral autonomic outflow are quantitative.

Issue Release: 2024

Non-Binary 2D Distribution Tool Maps Autonomic Nerve Fiber Clustering in Lumbosacral Ventral Roots of Rhesus Macaques.

Issue Release: 2024

Norepinephrine Reuptake Inhibition, an Emergent Treatment for Neurogenic Orthostatic Hypotension.

Issue Release: 2024

Distribution of alpha-synuclein in rat salivary glands.

Issue Release: 2024

The sublingual branch of the lingual nerve: Anatomical study and suggestion for a new terminology.

Issue Release: 2023

Comorbidity of cardiorespiratory and locomotor dysfunction following cervical spinal cord injury in the rat.

Issue Release: 2023

Beyond the Microbiota: Understanding the Role of the Enteric Nervous System in Parkinson\'s Disease from Mice to Human.

Issue Release: 2023

Synaptotagmin-7 facilitates acetylcholine release in splanchnic nerve-chromaffin cell synapses during nerve activity.

Issue Release: 2023

Intraoperative mapping of the sensory root of the trigeminal nerve in subjects with pontocerebellar angle pathology.

Issue Release: 2023

Microinjection of NMDA-neurotoxin into the superior salivatory nucleus of the rat: Short-term secretory and long-term drinking behavior effects.

Issue Release: 2023

Genetic encoding of an esophageal motor circuit.

Issue Release: 2022

Effect of Physical Training on the Morphology of Parasympathetic Atrial Ganglia after Unilateral Vagotomy in Rats.

Issue Release: 2022

An Exploration of the Sympathetic Component of the Recurrent Laryngeal Nerve.

Issue Release: 2022

Intrathecally administered substance P activated the spinal defecation center and enhanced colorectal motility in anesthetized rats.

Issue Release: 2022

Spinal Reflex Control of Arterial Blood Pressure: The Role of TRP Channels and Their Endogenous Eicosanoid Modulators.

Issue Release: 2022

An error in interpretation and real extraordinary electrocardiographic changes in patient with acute traumatic spondylolisthesis.

Issue Release: 2022

Spinal relay neurons for central control of autonomic pathways in a photoperiodic rodent.

Issue Release: 2021

Cerebellar projections to the macaque midbrain tegmentum: Possible near response connections.

Issue Release: 2021

A shape-adjusted ellipse approach corrects for varied axonal dispersion angles and myelination in primate nerve roots.

Issue Release: 2021

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