Microvessel Density (MVD) - Histology

What is Microvessel Density (MVD)?

Microvessel Density (MVD) refers to the number of microvessels per unit area of tissue. It is a crucial parameter in the field of Histology and is often used to assess angiogenesis, particularly in the context of cancer research.

Why is MVD Important?

MVD is significant because it serves as a surrogate marker for angiogenesis. High MVD is often associated with aggressive tumor behavior and poor prognosis. It helps in understanding the pathophysiology of diseases, particularly in determining the potential for metastasis in malignant tumors.

How is MVD Measured?

MVD is typically measured using immunohistochemistry (IHC) to stain endothelial cells, often using markers like CD31, CD34, or VEGF. The stained tissue sections are then examined under a microscope, and the number of microvessels is quantified in "hot spots" - areas with the highest microvessel concentration.

What are the Applications of MVD?

MVD has several applications in clinical and research settings. It is used to:

Assess the efficacy of anti-angiogenic therapies
Predict prognosis in cancer patients
Study the epidemiology of various diseases
Understand the mechanisms of angiogenesis

What are the Limitations of MVD?

While MVD is a valuable tool, it has its limitations. These include:

Inter-observer variability in counting microvessels
Variability in staining techniques
Potential for sampling error due to heterogeneity within the tumor
Requirement for specialized equipment and expertise

Future Directions

Future research aims to standardize MVD measurement techniques and develop automated systems for more accurate and reproducible results. Emerging technologies like multispectral imaging and AI-based image analysis are expected to enhance the precision and applicability of MVD measurements.

In conclusion, MVD is a pivotal parameter in histology, offering insights into angiogenesis and serving as a vital tool in cancer prognosis and research. Despite its limitations, ongoing advancements hold promise for its enhanced application in medical science.

Relevant Publications

Scorpiones, Scolopendra and Gekko Inhibit Lung Cancer Growth and Metastasis by Ameliorating Hypoxic Tumor Microenvironment via PI3K/AKT/mTOR/HIF-1α Signaling Pathway.

Issue Release: 2024

Microvessel barrier dysfunction in sinonasal inverted papilloma-associated squamous cell carcinoma and its manifestation in dynamic contrast-enhanced MRI.

Issue Release: 2024

Histopathological growth pattern and vessel co-option in intrahepatic cholangiocarcinoma.

Issue Release: 2024

Characteristics of mast cell infiltration in lung adenocarcinoma and its impact on prognosis.

Issue Release: 2024

Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism.

Issue Release: 2024

Predictive value of preoperative CT enhancement rate and CT perfusion parameters in colorectal cancer.

Issue Release: 2024

Diagnostic value of one-stop CT energy spectrum and perfusion for angiogenesis in colon and rectum cancer.

Issue Release: 2024

Correlation analysis of bone marrow microvessel density and miRNA expression on drug resistance in patients with chronic myelogenous leukemia after tyrosine kinase inhibitor treatment.

Issue Release: 2024

Sodium tanshinone IIA sulfonate inhibits tumor growth via miR-138 upregulation in intermittent hypoxia-induced xenograft mice.

Issue Release: 2024

N-myc downstream-regulated gene 1 can promote vasculogenic mimicry and angiogenesis in urothelial carcinoma.

Issue Release: 2024

[F]FDG PET/CT Signal Correlates with Neoangiogenesis Markers in Patients with Fibrotic Interstitial Lung Disease Who Underwent Lung Biopsy: Implication for the Use of PET/CT in Diffuse Lung Diseases.

Issue Release: 2024

Multi-b-value DWI to evaluate the synergistic antiproliferation and anti-heterogeneity effects of bufalin plus sorafenib in an orthotopic HCC model.

Issue Release: 2024

Expression and significance of pigment epithelium-derived factor and vascular endothelial growth factor in colorectal adenoma and cancer.

Issue Release: 2024

Arterial supply and morphological characteristics of sympathetic neurons in the human superior cervical ganglion.

Issue Release: 2024

Downregulation of carbonic anhydrase IX expression in mouse xenograft nasopharyngeal carcinoma model via doxorubicin nanobubble combined with ultrasound.

Issue Release: 2024

Hirudin Enhances Perforator Flap Survival: Clinical Application Report and Mechanistic Exploration.

Issue Release: 2024

Monitoring imatinib decreasing pericyte coverage and HIF-1α level in a colorectal cancer model by an ultrahigh-field multiparametric MRI approach.

Issue Release: 2024

The combination of apatinib and antigen-specific DC-induced T cells exert antitumor effects by potently improving the immune microenvironment of osteosarcoma.

Issue Release: 2024

PD-L1 and VEGF dual blockade enhances anti-tumor effect on brain metastasis in hematogenous metastasis model.

Issue Release: 2024

Microvessel Density (MVD) in Patients with Osteosarcoma: A Systematic Review and Meta-Analysis.

Issue Release: 2024

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