Lapaquistat - Histology

Relevant Publications

Mevalonate Kinase Deficiency and Squalene Synthase Inhibitor (TAK-475): The Balance to Extinguish the Inflammation.

Issue Release: 2021

Repositioning of Tak-475 In Mevalonate Kinase Disease: Translating Theory Into Practice.

Issue Release: 2018

Pharmacokinetics of TAK-475, a Squalene Synthase Inhibitor, in Rats and Dogs.

Issue Release: 2016

Characterization of Transporters in the Hepatic Uptake of TAK-475 M-I, a Squalene Synthase Inhibitor, in Rats and Humans.

Issue Release: 2016

Anti-inflammatory and cytoprotective effects of a squalene synthase inhibitor, TAK-475 active metabolite-I, in immune cells simulating mevalonate kinase deficiency (MKD)-like condition.

Issue Release: 2016

Squalene synthase inhibitor lapaquistat acetate: could anything be better than statins?

Issue Release: 2011

Lapaquistat acetate: development of a squalene synthase inhibitor for the treatment of hypercholesterolemia.

Issue Release: 2011

Molecular docking studies to map the binding site of squalene synthase inhibitors on dehydrosqualene synthase of Staphylococcus aureus.

Issue Release: 2010

Current and future pharmacologic options for the management of patients unable to achieve low-density lipoprotein-cholesterol goals with statins.

Issue Release: 2008

Lapaquistat acetate, a squalene synthase inhibitor, changes macrophage/lipid-rich coronary plaques of hypercholesterolaemic rabbits into fibrous lesions.

Issue Release: 2008

Gateways to clinical trials.

Issue Release: 2008

Emerging lipid-lowering drugs: squalene synthase inhibitors.

Issue Release: 2008

Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs.

Issue Release: 2007

Gateways to clinical trials.

Issue Release: 2007

Pharmacologic inhibition of squalene synthase and other downstream enzymes of the cholesterol synthesis pathway: a new therapeutic approach to treatment of hypercholesterolemia.

Issue Release: 0000

How do Gli Transcription Factors Function?

Why is Cystoscopy Performed?

How does histology help in diagnosing cataracts?

How Can Researchers Prepare for Ethics Committee Reviews?

Where is TrkB Receptor Expressed?

Why are Ion Channels and Receptors Important in Histology?

What is Membranous Nephropathy?

What are Microvascular Changes?

What Measures Can Enhance Security?

What is Histology Sample Storage?

Partnered Content Networks

Relevant Topics