Increased Myoglobin - Histology

What is Myoglobin?

Myoglobin is a heme protein primarily found in muscle tissue. It serves as an oxygen reservoir and facilitates oxygen transport within muscle cells. Structurally similar to hemoglobin, myoglobin consists of a single polypeptide chain and a heme group, which binds oxygen.

How is Myoglobin Detected in Histology?

In histological studies, myoglobin can be identified using specific immunohistochemical staining techniques. Antibodies against myoglobin are used to label muscle tissues, making it possible to visualize the protein under a microscope. This staining is particularly useful in differentiating between various types of muscle fibers and detecting muscle damage.

What Causes Increased Myoglobin Levels?

Elevated myoglobin levels in tissues or blood can result from several conditions. Muscle injury, such as that caused by intense exercise, trauma, or rhabdomyolysis, can lead to increased myoglobin release into the bloodstream. Other causes include myocardial infarction and certain genetic muscle diseases like muscular dystrophy.

What are the Histological Changes Associated with Increased Myoglobin?

Increased myoglobin levels can lead to various histological changes in muscle tissue. During muscle injury, histological analysis may reveal necrosis of muscle fibers, inflammatory cell infiltration, and edema. Chronic conditions like muscular dystrophy may show progressive degeneration of muscle fibers and replacement with fibrous and fatty tissue.

What are the Clinical Implications of Increased Myoglobin?

Clinically, elevated myoglobin levels can indicate acute muscle damage or disease. In the context of acute conditions like rhabdomyolysis, high myoglobin levels can lead to acute kidney injury due to its toxic effects on renal tubules. Therefore, timely intervention is crucial to prevent renal complications. Myoglobin levels are also monitored in patients with acute coronary syndrome to assess myocardial damage.

How is Increased Myoglobin Managed?

Management of elevated myoglobin involves addressing the underlying cause of muscle damage. In cases of rhabdomyolysis, treatment may include aggressive hydration to prevent kidney injury and correcting electrolyte imbalances. For chronic muscle diseases, management focuses on symptomatic relief and slowing disease progression through physical therapy, medications, and sometimes surgical interventions.

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Impact of Refrigerated Storage on Microbial Growth, Color Stability, and pH of Turkey Thigh Muscles.

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Protective role of alpha-lipoic acid against rhabdomyolysis-induced acute kidney injury in rats.

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Continuous measurements of respiratory muscle blood flow & oxygen consumption using non-invasive FD-NIRS & DCS.

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Effects of chitosan-based packaging film crosslinked with nanoencapsulated star anise essential oil and superchilled storage on the quality of rabbit meat patties.

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Effects of Supercritical CO Treatment on Color, Lipid Oxidation, Heme Iron, Non-Heme Iron and Metmyoglobin Contents in Ground Pork.

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Correlation Between Early Serum Myoglobin Levels and the Incidence and Prognosis of Intensive Care Unit-Acquired Weakness (ICU-AW) in Septic Shock Patients: A Comparative Study.

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Development and validation of LCMM prediction algorithms to estimate recovery pattern of postoperative AKI in type A aortic dissection: a retrospective study.

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Dynamic increase in myoglobin level is associated with poor prognosis in critically ill patients: a retrospective cohort study.

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Oxidized myoglobin: Revealing new perspectives and insights on factors affecting the water retention of myofibrillar proteins.

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Paraspinal muscle oxygenation and mechanical efficiency are reduced in individuals with chronic low back pain.

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Endurance training increases mitochondrial myoglobin and enhances its interaction with complex IV in rat plantaris muscle.

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Renoprotective effect of thymoquinone against rhabdomyolysis-induced acute kidney injury in the rat model.

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Roles of programmed death-1 and muscle innate lymphoid cell-derived interleukin 13 in sepsis-induced intensive care unit-acquired weakness.

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Spectrum of Kidney Biopsy Findings Associated With Methamphetamine Use.

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The clinical characteristics analysis of serum markers for the cardiovascular system in early-stage COVID-19 patients.

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Myoglobin saturation as an intracellular indicator for transfusion need in oncology patients.

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Comparative analysis of neurofilaments and biomarkers of muscular damage in amyotrophic lateral sclerosis.

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Keeping quality of raw ground beef patties fortified with polyphenols extracted from Acacia mearnsii bark and leaves.

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Effects of Intrahypothalamic Administration of microRNA Inhibitors and Mimetics on Blood Plasma Biomarkers in the Rat Aging.

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Light wavelengths that induce oxidation of oxymyoglobin in meat.

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