Immunoreceptor Tyrosine Based Activation Motifs (itams) - Histology

Relevant Publications

Phospho-mimetic CD3ε variants prevent TCR and CAR signaling.

Issue Release: 2024

Nonsense CD247 mutations show dominant-negative features in TCR expression and function.

Issue Release: 2024

Molecular regulatory mechanism of LILRB4 in the immune response.

Issue Release: 2023

Tuned activation of MSLN-CAR T cells induces superior antitumor responses in ovarian cancer models.

Issue Release: 2023

Enhancing the antitumor immunity of T cells by engineering the lipid-regulatory site of the TCR/CD3 complex.

Issue Release: 2022

Selective suppression of IL-10 transcription by calcineurin in dendritic cells through inactivation of CREB.

Issue Release: 2022

Balancing activation and co-stimulation of CAR tunes signaling dynamics and enhances therapeutic potency.

Issue Release: 2022

Structural principles of B-cell antigen receptor assembly.

Issue Release: 2022

Docking of Syk to FcεRI is enhanced by Lyn but limited in duration by SHIP1.

Issue Release: 2022

The ubiquitous role of spleen tyrosine kinase (Syk) in gut diseases: From mucosal immunity to targeted therapy.

Issue Release: 2021

Multi-scale simulations of the T cell receptor reveal its lipid interactions, dynamics and the arrangement of its cytoplasmic region.

Issue Release: 2021

CAR T cells in solid tumors: challenges and opportunities.

Issue Release: 2021

A MALT1 inhibitor suppresses human myeloid DC, effector T-cell and B-cell responses and retains Th1/regulatory T-cell homeostasis.

Issue Release: 2020

Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy.

Issue Release: 2020

Molecular Dynamics of the Recruitment of Immunoreceptor Signaling Module DAP12 Homodimer to Lipid Raft Boundary Regulated by PIP2.

Issue Release: 2020

Fc Receptor-Like 1 as a Promising Target for Immunotherapeutic Interventions of B-Cell-Related Disorders.

Issue Release: 2019

Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells.

Issue Release: 2019

The activation of immunoglobulin G Fc receptors (FcγRs) with immunoreceptor tyrosine-based activation motifs (ITAMs) promotes cognitive impairment in aged rats with diabetes.

Issue Release: 2019

The structural basis for membrane assembly of immunoreceptor signalling complexes.

Issue Release: 2019

Combinatorial diversity of Syk recruitment driven by its multivalent engagement with FcεRIγ.

Issue Release: 2019

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