Bosutinib - Histology

Mechanism of Action

The primary mechanism of action of bosutinib involves the inhibition of the BCR-ABL kinase. This kinase is a result of a chromosomal translocation known as the , which is a hallmark of CML. Bosutinib binds to the ATP-binding site of the BCR-ABL protein, preventing its activation and subsequent signaling pathways that lead to cell proliferation.

Histological Changes Induced by Bosutinib

Clinical Implications

Side Effects and Histological Impact

Histological Techniques for Monitoring

Future Directions




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